Publications with work performed at FCULMF, 2015 to present:

  1. Diallo M, Pimenta C, Murtinheira F, Martins-Alves D, Pinto FR, da Costa AA, Letra-Vilela R, Martin V, Rodriguez C, Rodrigues MS, Herrera F (2024) Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor. Cell Oncol, :. DOI: 10.1007/s13402-023-00911-9
  2. Teixeira A, Noronha H, Sebastiana M, Fortes AM, Gerós H (2022) A proteomic analysis shows the stimulation of light reactions and inhibition of the Calvin cycle in the skin chloroplasts of ripe red grape berries. Front Plant Sci, 13:1014532. DOI: 10.3389/fpls.2022.1014532
  3. Caetano S, Garcia AR, Figueira I, Brito MA (2023) MEF2C and miR-194-5p: New Players in Triple Negative Breast Cancer Tumorigenesis. Int J Mol Sci, 24(18):14297. DOI: 10.3390/ijms241814297
  4. Ferreira-Peralta P, França B, Murtinheira F, Rodrigues MS, Herrera F (2024) Is spastic ataxia 8 a protein misfolding disorder?. Biochim Biophys Acta Mol Basis Dis, 1870(1):166882. DOI: 10.1016/j.bbadis.2023.166882
  5. Godinho-Pereira J, Vaz D, Figueira I, Aniceto-Romão J, Krizbai I, Malhó M, Rocha J, Carvalheiro MC, Simões S, Gaspar MM, Brito MA (2023) Breast Cancer Brain Metastases: Implementation and Characterization of a Mouse Model Relying on Malignant Cells Inoculation in the Carotid Artery. Cells, 12(16):2076. DOI: 10.3390/cells12162076
  6. Garcia AR, Mendes A, Custódia C, Faria CC, Barata JT, Malhó R, Figueira I, Brito MA (2023) Abrogating Metastatic Properties of Triple-Negative Breast Cancer Cells by EGFR and PI3K Dual Inhibitors. Cancers, 15(15):3973. DOI: 10.3390/cancers15153973
  7. Fernandes BF, Silva N, Marques JF, Da Cruz MB, Tiainen L, Gasik M, Carvalho O, Silva FS, Caramês J, Mata A (2023) Bio-Piezoelectric Ceramic Composites for Electroactive Implants-Biological Performance. Biomimetics, 8(4):338. DOI: 10.3390/biomimetics8040338
  8. Leitão MIPS, Turos-Cabal M, Sanchez-Sanchez AM, Gomes C, Fernandez VM, Herrera F, Petronilho A (2023) Antitumor Activity and Reductive Stress by Platinum(II) N-Heterocyclic Carbenes based on Guanosine. Chemistry, 29(40):e202301078. DOI: 10.1002/chem.202301078
  9. Railean V, Rodrigues CS, Ramalho SS, Silva IAL, Bartosch J, Farinha CM, Pankonien I, Amaral MD (2023) Personalized medicine: Function of CFTR variant p.Arg334Trp is rescued by currently available CFTR modulators. Front Mol Biosci, 10:1155705. DOI: 10.3389/fmolb.2023.1155705
  10. dos Santos PG, Soares AR, Thorsteinsdóttir S, Rodrigues G (2023) Preparation of 3D Decellularized Matrices from Fetal Mouse Skeletal Muscle for Cell Culture. J Vis Exp, (193):. DOI: 10.3791/65069
  11. Bacalhau M, Ferreira FC, Silva IAL, Buarque CD, Amaral MD, Lopes-Pacheco M (2023) Additive Potentiation of R334W-CFTR Function by Novel Small Molecules. J Pers Med, 13(1):102. DOI: 10.3390/jpm13010102
  12. Sebastiana M, Serrazina S, Monteiro F, Wipf D, Fromentin J, Teixeira R, Malhó R, Courty P-E (2023) Nitrogen Acquisition and Transport in the Ectomycorrhizal Symbiosis—Insights from the Interaction between an Oak Tree and Pisolithus tinctorius. Plants, 12(1):10. DOI: 10.3390/plants12010010
  13. Moreira GG, Gomes CM (2023) Tau liquid-liquid phase separation is modulated by the Ca2+ -switched chaperone activity of the S100B protein. J Neurochem, 166(1):76-86. DOI: 10.1111/jnc.15756
  14. Bacalhau M, Ferreira FC, Kmit, A, Souza FR, da Silva VD, Pimentel AS, Amaral MD, Buarque CD, Lopes-Pacheco M (2023) Identification of novel F508del-CFTR traffic correctors among triazole derivatives. Eur J Pharmacol, 938:175396. DOI: 10.1016/j.ejphar.2022.175396
  15. Estorninho M, Chozas S, Mendes A, Colwell F, Abrantes I, Fonseca L, Fernandes P, Costa C, Máguas C, Correia O, Antunes C (2022) Differential Impact of the Pinewood Nematode on Pinus Species Under Drought Conditions. Front Plant Sci, 13:841707. DOI: 10.3389/fpls.2022.841707
  16. Rodenburg LW, Delpiano L, Railean V, Centeio R, Pinto MC, Smits SMA, van der Windt IS, van Hugten CFJ, van Beuningen SFB, Rodenburg RNP, van der Ent CK, Amaral MD, Kunzelmann K, Gray MA, Beekman JM, Amatngalim GD (2022) Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids. Int J Mol Sci, 23(20):12657. DOI: 10.3390/ijms232012657
  17. Encarnação S, de Mello-Sampayo C, Carrapiço B, Braz BS, Jordão AP, Peleteiro C, Catarino L, da Silva IBM,  Gouveia LF, Lima BS, Silva O (2022) Anacardium occidentale Bark as an Antidiabetic Agent. Plants, 11(19):2637. DOI: 10.3390/plants11192637
  18. Godinho-Pereira J, Lopes MD, Garcia AR, Botelho HM, Malhó R, Figueira I, Brito MA (2022) A Drug Screening Reveals Minocycline Hydrochloride as a Therapeutic Option to Prevent Breast Cancer Cells Extravasation across the Blood–Brain Barrier. Biomedicines, 10(8):1988. DOI: 10.3390/biomedicines10081988
  19. Ferreira JF, Silva IAL, Botelho HM, Amaral MD, Farinha CM (2022) Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids. Cells, 11(15):2295. DOI: 10.3390/cells11152295
  20. Franco F, Kausar S, Silva MFB, Guedes RC, Falcao AO, Brito MA (2022) Multi-Targeting Approach in Glioblastoma Using Computer-Assisted Drug Discovery Tools to Overcome the Blood–Brain Barrier and Target EGFR/PI3Kp110β Signaling. Cancers, 14(4):3506. DOI: 10.3390/cancers14143506
  21. Fernandes C, Palma E, Silva F, Belchior A, Pinto CIG, Guerreiro FJ, Botelho HM, Mendes F, Raposinho P, Paulo A (2022) Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus. Int J Mol Sci, 23(13):7238. DOI: 10.3390/ijms23137238
  22. de Almeida PG, Rifes P, Martins-Jesus AP, Pinheiro GG, Andrade RP, Thorsteinsdóttir S (2022) Cell–Fibronectin Interactions and Actomyosin Contractility Regulate the Segmentation Clock and Spatio-Temporal Somite Cleft Formation during Chick Embryo Somitogenesis. Cells, 11(13):2003. DOI: 10.3390/cells11132003
  23. Quaresma MC, Botelho HM, Pankonien I, Rodrigues CS, Pinto MC, Costa PR, Duarte A, Amaral MD (2022) Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition. Life Sci Alliance, 5(9):e202101326. DOI: 10.26508/lsa.202101326
  24. Mira AF, Marques L, Magalhães S, Rodrigues LR (2022) A Method to Measure the Damage Caused by Cell-Sucking Herbivores. In: Duque, P., Szakonyi, D. (eds) Environmental Responses in Plants. Methods in Molecular Biology, 2494:299-312. DOI: 10.1007/978-1-0716-2297-1_21
  25. Tomás A, da Fonseca IP, Valkenburg T, Rebelo MT (2022) Parasite island syndromes in the context of nidicolous ectoparasites: Fleas (Insecta: Siphonaptera) in wild passerine birds from Azores Archipelago. Parasitol Int, 89:102564. DOI: 10.1016/j.parint.2022.102564
  26. Lim SH, Snider J, Birimberg-Schwartz L, Ip W, Serralha JC, Botelho HM, Lopes-Pacheco M, Pinto MC, Moutaoufik MT, Zilocchi M, Laselva O, Esmaeili M, Kotlyar M, Lyakisheva A, Tang P, Vázquez LL, Akula I, Aboualizadeh F, Wong V, Grozavu I, Opacak-Bernardi T, Yao Z, Mendoza M, Babu M, Jurisica I, Gonska T, Bear CE, Amaral MD, Stagljar I (2022) CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system. Mol Syst Biol, 18(2):e10629. DOI: 10.15252/msb.202110629
  27. Murtinheira F, Migueis M, Letra-Vilela R, Diallo M, Quezada A, Valente CA, Oliva A, Rodriguez C, Martin V, Herrera F (2022) Sacsin Deletion Induces Aggregation of Glial Intermediate Filaments. Cells, 11(2):299. DOI: 10.3390/cells11020299
  28. Rodrigues AV, Valério-Bolas A, Alexandre-Pires G, Pereira MA, Nunes T, Ligeiro D, da Fonseca IP, Santos-Gomes G (2022) Zoonotic Visceral Leishmaniasis: New Insights on Innate Immune Response by Blood Macrophages and Liver Kupffer Cells to Leishmania infantum Parasites. Biology, 11(1):100. DOI: 10.3390/biology11010100
  29. da Silva ACN, Costa AL, Teixeira A, Alpoim-Moreira J, Fernandes C, Fradinho MJ, Rebordão MR, Silva E, da Silva JF, Bliebernicht M, Alexandre-Pires G, Ferreira-Dias G (2022) Collagen and Microvascularization in Placentas From Young and Older Mares. Front Vet Sci, 8:772658. DOI: 10.3389/fvets.2021.772658
  30. Pinto MC, Botelho HM, Silva IAL, Railean V, Neumann B, Pepperkok R, Schreiber R, Kunzelmann K, Amaral MD (2022) Systems Approaches to Unravel Molecular Function: High-content siRNA Screen Identifies TMEM16A Traffic Regulators as Potential Drug Targets for Cystic Fibrosis. J Mol Biol, 434(5):167436. DOI: 10.1016/j.jmb.2021.167436
  31. Lopes-Pacheco M, Bacalhau M, Ramalho SS, Silva IAL, Ferreira FC, Carlile GW, Thomas DY, Farinha CM, Hanrahan JW, Amaral MD (2022) Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A. Cells, 11(1):136. DOI: 10.3390/cells11010136
  32. Ramalho SS, Silva IAL, Amaral MD, Farinha CM (2022) Rare Trafficking CFTR Mutations Involve Distinct Cellular Retention Machineries and Require Different Rescuing Strategies. Int J Mol Sci, 23(1):24. DOI: 10.3390/ijms23010024
  33. Simões FB, Kmit A, Amaral MD (2021) Cross-talk of inflammatory mediators and airway epithelium reveals the cystic fibrosis transmembrane conductance regulator as a major target. ERJ Open Res, 7(4):00247-2021. DOI: 10.1183/23120541.00247-2021
  34. Pinto MC, Quaresma MC, Silva IAL, Railean V, Ramalho SS, Amaral MD (2021) Synergy in Cystic Fibrosis Therapies: Targeting SLC26A9. Int J Mol Sci, 22(33):13064. DOI: 10.3390/ijms222313064
  35. Moreira GG, Cantrelle F-X, Quezada A, Carvalho FS, Cristóvão JS, Sengupta U, Puangmalai N, Carapeto AP, Rodrigues MS, Cardoso I, Fritz G, Herrera F, Kayed R, Landrieu I, Gomes CM (2021) Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding. Nat Commun, 12(1):6292. DOI: 10.1038/s41467-021-26584-2
  36. Casimiro MH, Pereira A, Leal JP, Rodrigues G, Ferreira LM (2021) Chitosan/PVA Based Membranes Processed by Gamma Radiation as Scaffolding Materials for Skin Regeneration. Membranes, 11(8):561. DOI: 10.3390/membranes11080561
  37. Godinho-Pereira J, Garcia AR, Figueira I, Malhó R, Brito MA (2021) Behind Brain Metastases Formation: Cellular and Molecular Alterations and Blood-Brain Barrier Disruption. Int J Mol Sci, 22(13):7057. DOI: 10.3390/ijms22137057
  38. Santos L, Mention K, Cavusoglu-Doran K, Sanz DJ,  Bacalhau M,  Lopes-Pacheco M, Harrison PT,  Farinha CM (2021) Comparison of Cas9 and Cas12a CRISPR editing methods to correct the W1282X-CFTR mutation. J Cyst Fibros, in press. DOI: 10.1016/j.jcf.2021.05.014
  39. Seabra SG, Rodrigues ASB, Silva SE, Neto AC, Pina-Martins F, Marabuto E, Thompson V, Wilson MR, Yurtsever S, Halkka A, Rebelo MT, Borges PAV, Quartau JA, Jiggins CD, Paulo OS (2021) Population structure, adaptation and divergence of the meadow spittlebug, Philaenus spumarius (Hemiptera, Aphrophoridae), revealed by genomic and morphological data. PeerJ, 9:e11425. DOI: 10.7717/peerj.11425
  40. Silva IAL,  Railean V,  Duarte A,  Amaral MD (2021) Personalized Medicine Based on Nasal Epithelial Cells: Comparative Studies with Rectal Biopsies and Intestinal Organoids. J Pers Med, 11(5):421. DOI: 10.3390/jpm11050421
  41. Figueira I, Godinho-Pereira J, Galego S,  Maia J,  Haskó J,  Molnár K, Malhó R,  Costa-Silva B, Wilhelm I, Krizbai IA, Brito MA (2021) MicroRNAs and Extracellular Vesicles as Distinctive Biomarkers of Precocious and Advanced Stages of Breast Cancer Brain Metastases Development. Int J Mol Sci. 22(10):5214. DOI: 10.3390/ijms22105214
  42. Ferreira M, Pinto SN, Aires-da-Silva F, Bettencourt A, Aguiar SI, Gaspar MM (2021) Liposomes as a Nanoplatform to Improve the Delivery of Antibiotics into Staphylococcus aureus Biofilms. Pharmaceutics, 13(3):321. DOI: 10.3390/pharmaceutics13030321
  43. Figueira I, Galego S, Custódio-Santos T, Vicente R, Molnár K, Haskó J, Malhó R, Videira M, Wilhelm I, Krizbai I, Brito MA (2021) Picturing Breast Cancer Brain Metastasis Development to Unravel Molecular Players and Cellular Crosstalk. Cancers, 13(4):910. DOI: 10.3390/cancers13040910
  44. Serrazina S, Machado H, Costa RL, Duque P, Malhó R (2021) Expression of Castanea crenata allene oxide synthase in Arabidopsis improves the defense to Phytophthora cinnamomi. Front Plant Sci, 12:628697. DOI: 10.3389/fpls.2021.628697
  45. Galego S,  Kauppila LA, Malhó R, Pimentel J, Brito MA (2021) Myocyte Enhancer Factor 2C as a New Player in Human Breast Cancer Brain Metastases. Cells, 10(2):378. DOI: 10.3390/cells10020378
  46. Hagemeijer MC,  Vonk AM,  Awatade NT,  Silva IAL,  Tischer C,  Hilsenstein V, Beekman JM, Amaral MD,  Botelho HM (2020) An open-source high-content analysis workflow for CFTR function measurements using the forskolin-induced swelling assay. Bioinformatics, btaa1073. DOI: 10.1093/bioinformatics/btaa1073
  47. Silva IAL, Duarte A, Marson FAL, Centeio R, Doušová T, Kunzelmann K, Amaral MD (2020) Assessment of distinct electrophysiological parameters in rectal biopsies for the choice of the best diagnosis/prognosis biomarkers for cystic fibrosis. Front Physiol, 11:604580. DOI: 10.3389/fphys.2020.604580
  48. Tomás A, da Fonseca IP, Valkenburg T, Rebelo MT (2021) Louse flies in Azorean and mainland populations of four Passeriformes species: A new perspective to parasite Island syndromes. Int J Parasitol Parasites Wildl, 14:33-40. DOI: 10.1016/j.ijppaw.2020.12.004
  49. Quaresma MC, Pankonien I, Clarke LA, Sousa LS, Silva IAL, Railean V, Doušová T, Fuxe J, Amaral MD (2020) Mutant CFTR drives TWIST1 mediated epithelial-mesenchymal transition. Cell Death Dis, 11(10):920. DOI: 10.1038/s41419-020-03119-z
  50. Sousa L, Pankonien I, Simões FB, Chanson M, Amaral MD (2020) Impact of KLF4 on Cell Proliferation and Epithelial Differentiation in the Context of Cystic Fibrosis. Int J Mol Sci, 21(18):6717. DOI: 10.3390/ijms21186717
  51. Caperta AD, Róis AS, Teixeira G, Garcia‐Caparros P, Flowers TJ (2020) Secretory structures in plants: Lessons from the Plumbaginaceae on their origin, evolution and roles in stress tolerance. Plant Cell Environ, 43(12), 2912–2931. DOI: 10.1111/pce.13825
  52. Silva IAL, Doušová T, Ramalho S, Centeio R, Clarke LA, Railean V, Botelho HM, Holubová A, Valášková I, Yeh J-T, Hwang T-C, Farinha CM, Kunzelmann K, Amaral MD (2020) Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A>G. Biochim Biophys Acta Mol Basis Dis, 1866(11):165905. DOI: 10.1016/j.bbadis.2020.165905
  53. Santos JD, Pinto FR, Ferreira JF, Amaral MD, Zaccolo M, Farinha CM (2020) Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation. Biochem J, 477(13):2561–2580. DOI: 10.1042/BCJ20200287
  54. Lopes-Pacheco M, Silva IAL, Turner MJ, Carlile GW, Sondo E, Thomas DY, Pedemonte N, Hanrahan JW, Amaral MD (2020) Characterization of the mechanism of action of RDR01752, a novel corrector of F508del-CFTR. Biochem Pharmacol, 180, 114133. DOI: 10.1016/j.bcp.2020.114133
  55. Sousa L, Pankonien I, Clarke LA, Silva I, Kunzelmann K, Amaral MD (2020) KLF4 acts as a wt-CFTR suppressor through an AKT-mediated pathway. Cells, 9(7). DOI: 10.3390/cells9071607
  56. Vonk AM, van Mourik P, Ramalho AS, Silva IAL, Statia M, Kruisselbrink E, Suen SWF, Dekkers JF, Vleggaar FP, Houwen RHJ, Mullenders J, Boj SF, Vries R, Amaral MD, de Boeck K, van der Ent CK, Beekman JM (2020). Protocol for application, standardization and validation of the forskolin-induced swelling assay in cystic fibrosis human colon organoids. STAR Protoc, 1(1):100019. DOI: 10.1016/j.xpro.2020.100019
  57. Khmelinskaia A, Marquês JMT, Bastos AEP, Antunes CAC, Bento-Oliveira A, Scolari S, Lobo GMS, Malhó R, Herrmann A, Marinho HS, de Almeida RFM (2020) Liquid-ordered phase formation by mammalian and yeast sterols: a common feature with organizational differences. Front Cell Dev Biol, 8, 337. DOI: 10.3389/fcell.2020.00337
  58. Figueiredo AM, Villacampa P, Diéguez-Hurtado R, Lozano JJ, Kobialka P, Cortazar AR, Martinez-Romero A, Angulo-Urarte A, Franco CA, Claret M, Aransay AM, Adams RH, Carracedo A, Graupera M (2020) Phosphoinositide 3-Kinase–Regulated Pericyte Maturation Governs Vascular Remodeling. Circulation, 142:688–704. DOI: 10.1161/CIRCULATIONAHA.119.042354
  59. Pinto MC, Schreiber R, Lérias J, Ousingsawat J, Duarte A, Amaral M, Kunzelmann K (2020) Regulation of TMEM16A by CK2 and its role in cellular proliferation. Cells, 9(5). DOI: 10.3390/cells9051138
  60. Cortinhas A, Caperta AD, Teixeira G, Carvalho L, Abreu MM (2020) Harnessing sediments of coastal aquaculture ponds through technosols construction for halophyte cultivation using saline water irrigation. J Environ Manage, 261, 109907. DOI: 10.1016/j.jenvman.2019.109907
  61. Correia S, Santos M, Glińska S, Gapińska M, Matos M, Carnide V, Schouten R, Silva AP, Gonçalves B (2020) Effects of exogenous compound sprays on cherry cracking: skin properties and gene expression. J Sci Food Agric, 100(7), 2911–2921. DOI: 10.1002/jsfa.10318
  62. Marques NT, Filipe A, Pinto P, Barroso J, Trindade H, Power DM, Figueiredo AC (2020) Trichome density in relation to volatiles emission and 1,8-cineole synthase gene expression in Thymus albicans vegetative and reproductive organs. Chemistry & Biodiversity, 17(3), e1900669. DOI: 10.1002/cbdv.201900669
  63. Sereno M, Haskó J, Molnár K, Medina SJ, Reisz Z, Malhó R, Videira M, Tiszlavicz L, Booth SA, Wilhelm I, Krizbai IA, Brito MA (2020) Downregulation of circulating miR 802-5p and miR 194-5p and upregulation of brain MEF2C along breast cancer brain metastasization. Mol Oncol, 14(3):520–538. DOI: 10.1002/1878-0261.12632
  64. Amaral MD, Beekman JM (2020) Activating alternative chloride channels to treat CF: Friends or Foes?: Report on the Meeting of the Basic Science Working Group in Dubrovnik, Croatia. J Cyst Fibros, 19(1):11–15. DOI: 10.1016/j.jcf.2019.10.005
  65. Amaral MD, Hutt DM, Tomati V, Botelho HM, Pedemonte N (2020) CFTR processing, trafficking and interactions. J Cyst Fibros, 19 Suppl 1, S33–S36. DOI: 10.1016/j.jcf.2019.10.017
  66. Simão M, Moço M, Marques L, Santos R (2020) Characterization of the glycans involved in sea urchin Paracentrotus lividus reversible adhesion. Marine Biology, 167(9), 125. DOI:  10.1007/s00227-020-03707-9
  67. Garcia AR, Godinho-Pereira J, Figueira I, Malhó R, Brito MA (2019) Replicating the blood- brain barrier properties in an in vitro model: effects of hydrocortisone and/or shear stress. Archives of Anatomy, 8 (2):1-20.
  68. Vaz Dias F, Serrazina S, Vitorino M, Marchese D, Heilmann I, Godinho M, Rodrigues M, Malhó R (2019) A role for diacylglycerol kinase 4 in signalling crosstalk during Arabidopsis pollen tube growth. New Phytol 222(3), 1434–1446. DOI: 10.1111/nph.15674
  69. Palma E, Botelho HM, Morais GR, Rodrigues I, Santos IC, Campello MPC, Raposinho P, Belchior A, Gomes SS, Araújo MF, Correia I, Ribeiro N, Gama S, Mendes F, Paulo A (2019) Unravelling the antitumoral potential of novel bis(thiosemicarbazonato) Zn(II) complexes: structural and cellular studies. J Biol Inorg Chem, 24(1):71–89. DOI: 10.1007/s00775-018-1629-6
  70. Awatade NT, Ramalho S, Silva IAL, Felício V, Botelho HM, de Poel E, Vonk A, Beekman JM, Farinha CM, Amaral MD (2019) R560S: A class II CFTR mutation that is not rescued by current modulators. J Cyst Fibros, 18(2):182–189. DOI: 10.1016/j.jcf.2018.07.001
  71. Santos JD, Canato S, Carvalho AS, Botelho HM, Aloria K, Amaral MD, Matthiesen R, Falcão AO, Farinha CM (2019) Folding status is determinant over traffic-competence in defining CFTR interactors in the endoplasmic reticulum. Cells, 8(4):353. DOI: 10.3390/cells8040353
  72. Loureiro CA, Santos JD, Matos AM, Jordan P, Matos P, Farinha CM, Pinto FR (2019) Network biology identifies novel regulators of CFTR trafficking and membrane stability. Front Pharmacol, 10, 619. DOI: 10.3389/fphar.2019.00619
  73. Patel W, Moore PJ, Sassano MF, Lopes-Pacheco M, Aleksandrov AA, Amaral MD, Tarran R, Gray MA (2019) Increases in cytosolic Ca2+ induce dynamin- and calcineurin-dependent internalisation of CFTR. Cell Mol Life Sci, 76(5):977–994. DOI: 10.1007/s00018-018-2989-3
  74. Simões FB, Quaresma MC, Clarke LA, Silva IAL, Pankonien I, Railean V, Kmit A, Amaral MD (2019) TMEM16A chloride channel does not drive mucus production. Life Sci Alliance, 2(6). DOI: 10.26508/lsa.201900462
  75. Dias JNR, Aguiar SI, Pereira DM, André AS, Gano L, Correia JDG, Carrapiço B, Rütgen B, Malhó R, Peleteiro C, Goncalves J, Rodrigues CMP, Gil S, Tavares L, Aires-da-Silva F (2018) The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma. Oncotarget, 9(47):28586-28598. DOI: 10.18632/oncotarget.25580
  76. Olivença DV, Uliyakina I, Fonseca LL, Amaral MD, Voit EO, Pinto FR (2018) A mathematical model of the phosphoinositide pathway. Sci Rep, 8(1):3904. DOI: 10.1038/s41598-018-22226-8
  77. Sampaio-Pinto V, Rodrigues SC, Laundos TL, Silva ED, Vasques-Nóvoa F, Silva AC, Cerqueira RJ, Resende TP, Pianca N, Leite-Moreira A, D’Uva G, Thorsteinsdóttir S, Pinto-do-Ó P, Nascimento DS (2018) Neonatal apex resection triggers cardiomyocyte proliferation, neovascularization and functional recovery despite local fibrosis. Stem Cell Reports, 10(3):860–874. DOI: 10.1016/j.stemcr.2018.01.042
  78. Casimiro MH, Gomes SR, Rodrigues G, Leal JP, Ferreira LM (2018) Chitosan/poly(vinylpyrrolidone) matrices obtained by gamma-irradiation for skin scaffolds: characterization and preliminary cell response studies. Materials (Basel), 11(12). DOI: 10.3390/ma11122535
  79. Lérias JR, Pinto MC, Botelho HM, Awatade NT, Quaresma MC, Silva IAL, Wanitchakool P, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD (2018) A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic. Biochim Biophys Acta Mol Cell Res, 1865(2):421–431. DOI: 10.1016/j.bbamcr.2017.11.009
  80. Sebastiana M, da Silva AB, Matos AR, Alcântara A, Silvestre S, Malhó R (2018) Ectomycorrhizal inoculation with Pisolithus tinctorius reduces stress induced by drought in cork oak. Mycorrhiza, 28(3):247–258. DOI: 10.1007/s00572-018-0823-2
  81. Camelo C, Vilas-Boas F, Cepeda AP, Real C, Barros-Martins J, Pinto F, Soares H, Marinho HS, Cyrne, L (2017) Opi1p translocation to the nucleus is regulated by hydrogen peroxide in Saccharomyces cerevisiae. Yeast, 34(9):383–395. DOI: 10.1002/yea.3240
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